Biomarkers – LIVETHEFUEL

Smart Nutrition and Health with Ari Tulla

Scott Mulvaney — Fri, 23 Jun 2023 11:00:00 +0000

Getting Smart With Our Nutrition & Health:

Ari Tulla is a San Francisco-based entrepreneur and the co-founder & CEO of the smart nutrition service, Elo, whose mission is to transform food from the leading cause of disease to medicine. Ari is also an active angel investor and advisor with a portfolio of 40 startups, including Virta Health, Good Eggs, and Ōura.

Previously, Ari was the CEO of Quest Analytics, the market leader in doctor data and network management. Ari led the company through a pivotal growth stage from $15M to $40M in revenue. Before joining Quest Analytics, Ari was co-founder and CEO of BetterDoctor, a doctor search engine.

When not working or co-parenting his two young children with his wife, Ari spends his time on the steep cliffs, powdery slopes, and big cold waves that only Northern California can offer.

Today’s Guest & Resource Links:

Timestamped Show Notes:

00:30 – Introduction

11:15 – It’s also powerful in a way that, I became a believer of the idea of food as medicine. I always remind myself that I wake up, the kids are here, because food was medicine. We would not have done that. We would not have, they would not be here. So, I mean, it’s pretty powerful for them. They don’t know the story yet.

20:00 – Some of them actually are facts that you need to listen, it just took time to find the right people to start implementing the implementers, whether it be engineers, or just people who just decided to execute on the on the game plan and figure it out. All of a sudden we apply these discoveries that weren’t fully applied, they were implemented before.

32:45 – That’s the point about this idea that we are looking at, you know, 12-13 biomarkers today on blood. Normally we think about blood biomarkers, we can think about, maybe sweat, but you can also think about digital biomarkers, like sleep and weight data, and your HRV and your activity, your heart rate, and many other things. So, one thing that we are trying to do a lot every day, is to really focus on understanding. How do we master nutrition? How do we build these things that are going to help you make that behavior change stick?

41:30 – So it’s so interesting, it’s why we alone, we talk about the nutrition problem, and we work today in a world of supplements and powders and stuff like that. It doesn’t mean we are going to stop there, we’re going to go into into food fairly quickly. But while we did start with the supplements, for example, I think it’s mind boggling and many people don’t know the fact that 20 million people in this country are taking supplements every day.

57:30 – In the bag, what we are sending to people and is handed back to that person, is blended specifically for that person. We have worked with really, really good people on the backend to make it scalable. This is something that has never really been done before. So every product we do, we try to be able to customize the protein, literally every protein bag we put out is gonna be different for that customer.

01:03:45 – Final Words Shown Below…

Our Final Words of the Show:

I think for me, the really the big thing is that the smart nutrition is something that you know, I believe it can become a real thing. Like a smartphone. What if we, now in the next decade, we invent this concept and take it further not us, but you know, hundreds of people, 1000 people, you know, hundreds of companies are gonna I hope adopt this idea. What if we, what if this becomes like a smartphone? What if half the people adopt smart interest and products that come from this world? What if we can actually with this sense, the way healthcare is perceived, and my big thing that I want to work on? I don’t know if it’s possible, but I think today that we might be able to figure it out, the code of health for humans by connecting us into more sensors and more biomarkers, and I think we can all find the universal theory of health, and it will look very different than what we have today.

When we have 100 different types of doctors. Looking at one part of your body. It’s like you’re blindfolded and you’re taxing the elephant from the nose and from the tail. That’s what the doctors do. and they don’t communicate to care, they don’t convene together to talk about your condition, the one doctor makes the call and then the other ones are not in the loop, they barely even see the data or the audit or the record.

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044: Silicon Valley, Cancer, Paleo, Sleep with Kevin Cottrell

Scott Mulvaney — Fri, 27 Jan 2017 17:00:00 +0000

Sleep focused, Paleo fed co-hosting:

The key to fitness, health and wellness are sleep. With poor sleep comes poor foundations. With poor foundations, we cannot build. Everything will come crashing down. People through time have worn a lack of sleep, due to hustle and getting stuff done, as a badge of honor. It’s time to put to bed that misconception with Episode 44 and our co-host Kevin Cottrell of fitfluentialradio.com and the HealthCast Now Podcast. Kevin found out the hard way. Through poor lifestyle and environmental choices, Kevin developed a Melanoma Cancer. Although he was a fit guy, his fitness was built upon a foundation of poor sleep. Kevin made critical lifestyle choices and is now healthier than ever. This episode is about the importance of sleep and lifestyle choices.

[spp-tweet tweet=”Light, Water, Magnetism, #Fat Kevin to #Fit Kevin #biohacker @kevincottrell @LIVETHEFUEL “]

On This Episode You Will Hear:

[spp-timestamp time=”01:22″] Kevin left College in the 80’s, he went back to where he grew up in the Palo Alto area. Kevin got involved in a number of startups in the 90’s, he was the typical Biz Dev Executive working 80-90 hours, traveling excessively, not getting enough sleep but he worked out every day. He thought he was on track. Then came the late 90’s into 2001 and the Dot Com crash. He had stock options on a startup that went public. The shares went from $100 a share to $1 a share in 60 days. An inner layer of stress started to form. Kevin was a guy, during that period of his life that thought sleep was overrated. As long as he kept working out things would be OK. Moving forward to the summer of 2006, Kevin had a mole removed, just a straight forward procedure. He gets a calling saying he needs an emergency procedure to remove some skin from his neck as he has a pretty serious Melanoma (Type of Skin Cancer).
[spp-timestamp time=”03:55″] One of the things Kevin got really good at as an Executive was when lots of drama and chaos comes up, Leadership and Executives fall into one of two camps, they are either a problem solver or you are part of the problem and chaos. Kevin had developed quite a good reputation as a problem solver so he began systematically asking questions at the Doctors office about the problem. He kept a level head despite the stress surging through his body.
[spp-timestamp time=”06:02″] At the point in time Kevin had the Cancer, he had the belief the Cancer was to do with family history but he came to find out since then it was much more to do with his lifestyle that put him at risk than it was any family history.
[spp-timestamp time=”07:33″] In 2009 Kevin was known as ‘Fat Kevin’. Now he wasn’t obese, but he looked obese. He was heavier and started to trend towards type 2 diabetes. This was from following the conventional advice from the Doctors. He was back to working out at four in the morning five times a week. He wasn’t getting enough sleep and was starting to move towards a different direction from a lifestyle stand point. He knew something was not right still. After listing to a Podcast about the Paleo Diet, Kevin knew he had to start looking into it. It wasn’t about the diet he was interested in, it was the lifestyle concept. A Doctor Friend, Dr. Jack Kruse, challenged him to go look at the incidents of melanoma and look at the further you are from the equator are the incidents. Kevin started to change his lifestyle. He began to focus on sleep and getting a healthy dose of sunlight. What happened was he got really healthy. His blood marker ratings went from a 6 to less than 1. He dramatically reduced the inflammation in his body. All by changing his environment and his lifestyle.

“Here’s a great before/after picture. First (left) was 2009. Right 2016. FYI, the weight difference is less than 10 lbs showing massive inflammation.” Do you sleep enough?!

[spp-timestamp time=”13:38″] Key Bio Markers, BUN to Creatinine Ratio, Blood Marker for Inflammation. Vitamin D levels. If you are in an environment where you have way too much blue light, you are indoors way too much, you can take Vitamin D Supplements or even Sun outside and remarkably our bodies do not react.
[spp-timestamp time=”16:28″] Kevin takes fewer supplements now. He concentrates on core lifestyle changes. Getting out and getting sunlight. Anchoring his Circadian rhythm.
[spp-timestamp time=”19:52″] Sleep is something we do have control over. The fastest way to wreck yourself is not to get enough sleep but also hormonally wack yourself by not sleeping correctly based on the light cycle.
[spp-timestamp time=”22:00″] Melatonin Production. Coincidences of low Melatonin and chronic diseases. Stop playing Russian Roulette with sleep. You can whack your Melatonin in a number of different ways. The first is not sleeping enough and not sleeping at the right times.
[spp-timestamp time=”24:50″] Your body needs to recover. Building a building or building a house. If your light/dark cycle and Circadian rhythm is out, you should be working our less, it is the quickest way to burnout. True health and wellness is built on the foundation of good sleep and good nutrition.
[spp-timestamp time=”33:12″] Focus on your foundation. Be clean. Eat real food that is nutrient dense. But if you are having problems focusing on the circadian alignment. Do some of the non-intuitive things, take a look at some of your lifestyle choices, are you poisoning yourself with blue light at night or are you falling asleep with the TV on in the bedroom or are your blood markers showing you have massive inflammation, focus on that then come back and look at your workouts. Workout less more is not better.
[spp-timestamp time=”35:41 “]Quality over quantity and less is more. Audit your light/dark cycle and sleep.
[spp-timestamp time=”37:39″] Inflammation is a fire going on in your body. FitFluential is re-framing the dialog so they can help people be their own health advocates.
[spp-timestamp time=”41:44″] Optimization and longevity
[spp-timestamp time=”42:41″] Don’t depend on healthcare, rebuild your foundations. Start surrounding yourself with knowledge.
[spp-timestamp time=”47:09″] Final Words @fitfluential on LIVETHEFUEL

Terms and Meanings

Circadian:
A circadian rhythm /sɜːrˈkeɪdiən/ is any biological process that displays an endogenous, entrainable oscillation of about 24 hours. These 24-hour rhythms are driven by a circadian clock, and they have been widely observed in plants, animals, fungi, and cyanobacteria.
Epigenetics:
The study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.
Melanoma:
A type of skin cancer that can spread to other organs in the body
Blood Marker for Inflammation:
If you have inflammation in a part of your body then extra protein is often released from the site of inflammation and circulates in the bloodstream. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and plasma viscosity (PV)blood tests are commonly used to detect this increase in protein
BUN Creatinine Ratio:
BUN/creatinine is the ratio between blood urea nitrogen (BUN), a waste product in the blood from protein metabolism, and creatinine. This ratio is used to help determine if kidney function is impaired due to a damaged or diseased kidneys or another factor outside of the kidneys.
Key Biomarkers:
Biomarkers are key molecular or cellular events that link a specific environmental exposure to a health outcome

Links and Resources

People Mentioned

Final Words

Effects on our lifestyle and our environment on the epigenetics side are the switches that you turn on or off. This is not only for health and wellness but also the dark side meaning, chronic diseases, and potentially early death. You should be focusing on optimizing our lifestyle and environment. In other words, we are not going to be optimized if we are inadvertently destroying our foundation.

Don’t fall prey to the argument of, I am going to just eat more healthy or exercise more because if the foundations are destroyed it is not going to work. Focus on sleep, focus on a circadian optimization plan, which is the light/dark cycle and eliminating the things that get you off track.

Action Steps

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